Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate

• 产品号: G0635
• CAS号: 148892-91-5
• 分子式: C10H14N6Na3O13P3
• 分子量: 588.141153
• 纯 度: ≥85% (HPLC)

产品别名

• 标题: Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate
• IUPAC标准名: trisodium hydrogen {[({[(2R,3S,4R,5R)-5-(2-amino-6-hydroxy-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]amino}phosphonate
• IUPAC传统名: trisodium hydrogen ({[(2R,3S,4R,5R)-5-(2-amino-6-hydroxypurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxyphosphinato)aminophosphonate
• 别名: Gpp(NH)p; 5′-Guanylyl-imidodiphosphate trisodium salt hydrate; β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate; GMP-PNP

产品登记号

• MDL号: MFCD00084770
• CAS号: 148892-91-5
• PubChem SID: 24895020

产品性质

• Empirical Formula (Hill Notation): C10H14N6Na3O13P3 · xH2O
• 纯度: ≥85% (HPLC)
• 运输包装: dry ice
• 外观: white powder
• 溶解度: H2O: soluble50 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36/37
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Binds and irreversibly activates G proteins.1 Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.2,3

详细说明 (简体中文)

Application
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Binds and irreversibly activates G proteins.1 Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.2,3