氯硝柳胺

• 产品号: N3510
• CAS号: 50-65-7
• 分子式: C13H8Cl2N2O4
• 分子量: 327.11962

产品别名

• 标题: Niclosamide
• IUPAC标准名: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
• IUPAC传统名: niclosamide
• 别名: 2′,5-二氯-4′-硝基水杨酸酰替苯胺; 2′,5-Dichloro-4′-nitrosalicylanilide

产品登记号

• CAS号: 50-65-7
• Beilstein号: 2820605
• PubChem SID: 24278585
• EC号: 200-056-8
• MDL号: MFCD00057597

产品性质

• Empirical Formula (Hill Notation): C13H8Cl2N2O4
• GHS警示词: Warning
• GHS危险声明: H400
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS警示性声明: P273
• RID/ADR: UN 3077 9/PG 3
• RTECS编号: VN8400000
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Application
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis1.
Biochem/physiol Actions
Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB- regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells1.

详细说明 (简体中文)

Application
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis1.
Biochem/physiol Actions
Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB- regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells1.