磺胺脒

• 产品号: S8751
• CAS号: 57-67-0
• 分子式: C7H10N4O2S
• 分子量: 214.2449

产品别名

• 标题: Sulfaguanidine
• IUPAC标准名: 1-(4-aminobenzenesulfonyl)guanidine
• IUPAC传统名: aterian
• 别名: 4-氨基-N-脒基苯磺酰胺; 4-Amino-N-guanylbenzenesulfonamide; 4-氨基-N-(氨基亚氨基甲基)苯磺酰胺; 4-Amino-N-(aminoiminomethyl)benzenesulfonamide

产品登记号

• PubChem SID: 24899810
• Beilstein号: 2695326
• CAS号: 57-67-0
• MDL号: MFCD00038136
• EC号: 200-345-9

产品性质

• Empirical Formula (Hill Notation): C7H10N4O2S
• 相关基因信息: human ... F2(2147), PRSS1(5644)
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: WO8575000
• 安全公开号: 26-36
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability2.
Biochem/physiol Actions
Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

详细说明 (简体中文)

Application
Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability2.
Biochem/physiol Actions
Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.