Monastrol

• 产品号: M8515
• CAS号: 254753-54-3
• 分子式: C14H16N2O3S
• 分子量: 292.35344
• 纯 度: ≥98% (HPLC)
• 保 存: protect from light

产品别名

• 标题: Monastrol
• IUPAC标准名: ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• IUPAC传统名: monastrol
• 别名: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester

产品登记号

• MDL号: MFCD00813077
• CAS号: 254753-54-3
• PubChem SID: 24897267

产品性质

• Empirical Formula (Hill Notation): C14H16N2O3S
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 熔点: 185-185.9 °C(lit.)
• 溶解度: DMSO: >5 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存条件: protect from light
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Packaging
Packaged under inert gas.
Biochem/physiol Actions
Monastrol is a potent, cell-permeant inhibitor of mitosis. Monastrol arrested cells are characterized by monopolar spindles. This phenotype is induced through specific disruption of mitotic molecular motor kinesin Eg5 with IC50 at 14 μM. No effect on other motor proteins and tubulin.

详细说明 (简体中文)

包装
Packaged under inert gas.
Biochem/physiol Actions
Monastrol is a potent, cell-permeant inhibitor of mitosis. Monastrol arrested cells are characterized by monopolar spindles. This phenotype is induced through specific disruption of mitotic molecular motor kinesin Eg5 with IC50 at 14 μM. No effect on other motor proteins and tubulin.