4′-Chlorodiazepam

• 产品号: C5174
• CAS号: 14439-61-3
• 分子式: C16H12Cl2N2O
• 分子量: 319.18528
• 纯 度: ≥98% (TLC)

产品别名

• 标题: 4′-Chlorodiazepam
• IUPAC标准名: 7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
• IUPAC传统名: 4-chlorodiazepam
• 别名: Ro 5-4864; Ro5-4864; 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

产品登记号

• PubChem SID: 24892765
• Beilstein号: 685202
• CAS号: 14439-61-3
• MDL号: MFCD00043406

产品性质

• Empirical Formula (Hill Notation): C16H12Cl2N2O
• 纯度: ≥98% (TLC)
• 相关基因信息: rat ... Tspo(24230)
• 溶解度: 2-hydroxypropyl-β-cyclodextrin: insoluble
• 溶解度: H2O: insoluble
• 毒品管制信息: regulated under CDSA - not available from Sigma-Aldrich Canada
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• RTECS编号: DF0500000
• 安全公开号: 22-24/25
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Peripheral benzodiazepine ligand useful in distinguishing central-type from peripheral-type benzodiazepine receptors.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective antagonist of the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

详细说明 (简体中文)

Application
Peripheral benzodiazepine ligand useful in distinguishing central-type from peripheral-type benzodiazepine receptors.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective antagonist of the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.