Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin_分子结构_CAS_219138-02-0)

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Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin
产品号	C5599	公司名称	Sigma Aldrich
CAS号	219138-02-0	公司网站	http://www.sigmaaldrich.com
分子式	C37H42F3N5O13	电话	1-800-521-8956
分子量	821.7502896	传真
纯度	≥95% (HPLC)	电子邮件
保存		Chembase数据库ID: 155097

产品价格信息

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产品别名

标题

Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin

IUPAC标准名

(4S)-4-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}butanoic acid

IUPAC传统名

(4S)-4-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}butanoic acid

别名

Cbz-IETD-AFC

产品登记号

MDL号	MFCD01318832
CAS号	219138-02-0

产品性质

Empirical Formula (Hill Notation)	C37H42F3N5O13
纯度	≥95% (HPLC)
相关基因信息	human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002)mouse ... CFLAR(117279), GZMB(171528)rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007)
MSDS下载	下载链接
个人保护装置	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度	-20°C
德国WGK号	3

产品详细信息

详细说明 (English)

Amino Acid Sequence
Z-Ile-Glu-Thr-Asp-AFC
Application
Fluorogenic substrate for caspase 8 and granzyme B.
Biochem/physiol Actions
IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

详细说明 (简体中文)