ATPO

• 产品号: A7845
• CAS号: 252930-37-3
• 分子式: C11H19N2O7P
• 分子量: 322.251521

产品别名

• 标题: ATPO
• IUPAC标准名: 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid
• IUPAC传统名: 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid
• 别名: (R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

产品登记号

• PubChem SID: 24278239
• CAS号: 252930-37-3
• MDL号: MFCD03452828

产品性质

• Empirical Formula (Hill Notation): C11H19N2O7P
• 相关基因信息: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)rat ... Gria1(50592), Grik1(29559), Grin2a(24409)
• 外观: solid
• 溶解度: 1 M NaOH: soluble7 mg/mL
• 溶解度: DMSO: insoluble
• 溶解度: H2O: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Application
The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO) is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA/GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA).

详细说明 (简体中文)

Biochem/physiol Actions
Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Application
The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO) is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA/GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA).