Wedelolactone

• 产品号: W4016
• CAS号: 524-12-9
• 分子式: C16H10O7
• 分子量: 314.2464
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Wedelolactone
• IUPAC标准名: 3,13,14-trihydroxy-5-methoxy-8,17-dioxatetracyclo[8.7.0.0^2,^7.0^1^1,^1^6]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-9-one
• IUPAC传统名: wedelolactone
• 别名: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one; 7-Methoxy-5,11,12-trihydroxycoumestan

产品登记号

• MDL号: MFCD07778564
• CAS号: 524-12-9
• PubChem SID: 24724667

产品性质

• Empirical Formula (Hill Notation): C16H10O7
• 纯度: ≥98% (HPLC)
• 外观: pale yellow solid
• 溶解度: DMSO: soluble >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H317
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 22-43
• 安全公开号: 36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

详细说明 (简体中文)

Biochem/physiol Actions
Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.