Rebeccamycin

• 产品号: R4900
• CAS号: 93908-02-2
• 分子式: C27H21Cl2N3O7
• 分子量: 570.37754
• 纯 度: ≥98% (HPLC)
• 保 存: protect from light

产品别名

• 标题: Rebeccamycin
• IUPAC标准名: 5,21-dichloro-23-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.0^2,^1^0.0^4,^9.0^1^1,^1^5.0^1^7,^2^2]tricosa-1(16),2(10),4,6,8,11(15),17(22),18,20-nonaene-12,14-dione
• IUPAC传统名: rebeccamycin

产品登记号

• CAS号: 93908-02-2
• MDL号: MFCD01718312
• PubChem SID: 24899375

产品性质

• 生物来源: from Saccharothrix aerocolonigenes
• Empirical Formula (Hill Notation): C27H21Cl2N3O7
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 相关基因信息: human ... TOP1(7150)mouse ... Prkca(18750)rat ... Prkca(24680)
• 外观: yellow solid
• 溶解度: DMSO: ≥3 mg/mL
• 溶解度: THF: soluble
• 保存条件: protect from light
• 保存温度: -20°C
• 德国WGK号: -

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,1 it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.2 Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.3

详细说明 (简体中文)

Biochem/physiol Actions
Rebeccamycin is an antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. As an antitumor agent,1 it is cytotoxic to tumor cell lines such as human lung adenocarcinoma, colon carcinoma and nasopharyngeal carcinoma, etc.2 Rebeccamycin intercalates into the DNA and is an inhibitor of topoisomerase I. It stabilizes the covalent topoisomerase I-DNA intermediate (the cleavable complex) resulting in increased DNA strand breaks.3