TN-16

• 产品号: T7580
• CAS号: 33016-12-5
• 分子式: C19H18N2O2
• 分子量: 306.35842
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: TN-16
• IUPAC标准名: 5-benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione
• IUPAC传统名: 5-benzyl-3-[1-(phenylamino)ethylidene]pyrrolidine-2,4-dione
• 别名: 3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione; NSC 239274

产品登记号

• CAS号: 33016-12-5

产品性质

• Empirical Formula (Hill Notation): C19H18N2O2
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥17 mg/mL
• GHS警示词: Warning
• GHS危险声明: H317-H400
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P280
• 危险公开号: 43-50/53
• 安全公开号: 36/37-60-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Inhibitor of microtubule assembly
TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. Recently, TN-16 has been shown to prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.

详细说明 (简体中文)

Biochem/physiol Actions
Inhibitor of microtubule assembly
TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. Recently, TN-16 has been shown to prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.