Zoniporide hydrochloride hydrate

• 产品号: SML0076
• CAS号: 241800-98-6(freebase)
• 分子式: C17H19ClN6O2
• 分子量: 374.82476
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Zoniporide hydrochloride hydrate
• IUPAC标准名: N-carbamimidoyl-5-cyclopropyl-1-(quinolin-4-yl)-1H-pyrazole-4-carboxamide hydrate hydrochloride
• IUPAC传统名: N-carbamimidoyl-5-cyclopropyl-1-(quinolin-4-yl)pyrazole-4-carboxamide hydrate hydrochloride
• 别名: N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate

产品登记号

• CAS号: 241800-98-6(freebase)
• MDL号: MFCD04113213

产品性质

• Empirical Formula (Hill Notation): C17H16N6O · xHCl · yH2O
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: H2O: soluble2 mg/mL, clear (warmed)
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.

详细说明 (简体中文)

Biochem/physiol Actions
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.