GPV574

• 产品号: SML0135
• CAS号: 635703-12-7
• 分子式: C23H30N2O3
• 分子量: 382.4959
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: GPV574
• IUPAC标准名: 1-(4-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-hydroxypropoxy}phenyl)ethan-1-one
• IUPAC传统名: 1-(4-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]-2-hydroxypropoxy}phenyl)ethanone
• 别名: 1-[4-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]-2-hydroxypropoxy]phenyl]-ethanone

产品登记号

• CAS号: 635703-12-7
• MDL号: MFCD20527325

产品性质

• Empirical Formula (Hill Notation): C23H30N2O3
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥10 mg/mL (warmed to 60°C)
• 保存温度: 2-8°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
GPV574 is a derivative of the Class 1C antiarrhythmic drug propafenone. GPV574 inhibits the delayed rectifier K+ channel HERG with similar affinity and time constant as propafenone (IC50 = 5 mM), but unlike the parent compound, does not remain permanently trapped in the channel pore. After wash-out of GPV574, channel activity is recovered within 60 seconds.

详细说明 (简体中文)

Biochem/physiol Actions
GPV574 is a derivative of the Class 1C antiarrhythmic drug propafenone. GPV574 inhibits the delayed rectifier K+ channel HERG with similar affinity and time constant as propafenone (IC50 = 5 mM), but unlike the parent compound, does not remain permanently trapped in the channel pore. After wash-out of GPV574, channel activity is recovered within 60 seconds.