PF-477736

• 产品号: PZ0186
• CAS号: 952021-60-2
• 分子式: C22H25N7O2
• 分子量: 419.4796
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: PF-477736
• IUPAC标准名: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• IUPAC传统名: (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^4,^1^3]trideca-1,4(13),5,7,11-pentaen-6-yl]acetamide
• 别名: (2R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide; PF-00477736

产品登记号

• CAS号: 952021-60-2
• MDL号: MFCD16038847

产品性质

• Empirical Formula (Hill Notation): C22H25N7O2
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: ≥20 mg/mL
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-00477736 is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. The compound abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin.

详细说明 (English)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-00477736 is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. The compound abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin.