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Avasimibe

产品号 PZ0190 公司名称 Sigma Aldrich
CAS号 166518-60-1 公司网站 http://www.sigmaaldrich.com
分子式 C29H43NO4S 电 话 1-800-521-8956
分子量 501.72102 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 72881

产品价格信息

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产品别名

标题
Avasimibe
IUPAC标准名
1-({[2,6-bis(propan-2-yl)phenoxy]sulfonyl}amino)-2-[2,4,6-tris(propan-2-yl)phenyl]ethan-1-one
IUPAC传统名
1-[(2,6-diisopropylphenoxysulfonyl)amino]-2-(2,4,6-triisopropylphenyl)ethanone
别名
CI-1011; PD 148515; [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid

产品登记号

MDL号 MFCD00934956
CAS号 166518-60-1

产品性质

Empirical Formula (Hill Notation) C29H43NO4S
纯度 ≥98% (HPLC)
外观 white to tan powder
溶解度 DMSO: ≥40 mg/mL
MSDS下载 下载链接
保存温度 room temp
德国WGK号 3

产品详细信息

详细说明 (English)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. It was originally developed as an antilepic drug, and was shown to significantly reduce plasma total triglyceride and VLDL-cholesterol, but later clinical trials were disappointing. ACAT has also been investigated as a potential therapeutic target for Alzheimer′s disease. Recent studies have looked at the effects of avasimibe in reducing amyloid pathology by limiting generation and increasing clearance of diffusible amyloid-beta (Abeta).
详细说明 (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. It was originally developed as an antilepic drug, and was shown to significantly reduce plasma total triglyceride and VLDL-cholesterol, but later clinical trials were disappointing. ACAT has also been investigated as a potential therapeutic target for Alzheimer′s disease. Recent studies have looked at the effects of avasimibe in reducing amyloid pathology by limiting generation and increasing clearance of diffusible amyloid-beta (Abeta).

参考文献