Quinaprilat hydrate

• 产品号: Q0264
• CAS号: 82768-85-2(anhydrous)
• 分子式: C23H28N2O6
• 分子量: 428.47822
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Quinaprilat hydrate
• IUPAC标准名: (3S)-2-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrate
• IUPAC传统名: quinaprilat hydrate
• 别名: (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrate

产品登记号

• CAS号: 82768-85-2(anhydrous)
• MDL号: MFCD08060097

产品性质

• Empirical Formula (Hill Notation): C23H26N2O5 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 比旋光度: [α]/D +16 to +23 ( C=1, MeOH)
• 溶解度: DMSO: ≥23 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H400
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P301 + P310
• 危险公开号: 25-50
• 安全公开号: 45-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Quinaprilat is the active metabolite of Quinapril. It is an angiotensin converting enzyme (ACE) inhibitor, an antihypertensive used in treatment of congestive heart failure. Quinaprilat has high affinity to tissue ACE, and has been shown to improve impaired flow-dependent (endothelium-mediated) dilation (FDD) in patients with chronic heart failure compared to other ACE inhibitors with low affinity for tissue ACE.

详细说明 (简体中文)

Biochem/physiol Actions
Quinaprilat is the active metabolite of Quinapril. It is an angiotensin converting enzyme (ACE) inhibitor, an antihypertensive used in treatment of congestive heart failure. Quinaprilat has high affinity to tissue ACE, and has been shown to improve impaired flow-dependent (endothelium-mediated) dilation (FDD) in patients with chronic heart failure compared to other ACE inhibitors with low affinity for tissue ACE.