Securinine

• 产品号: SML0055
• CAS号: 5610-40-2
• 分子式: C13H15NO2
• 分子量: 217.2637
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Securinine
• IUPAC标准名: (1S,2R,8S)-14-oxa-7-azatetracyclo[6.6.1.0^1,^1^1.0^2,^7]pentadeca-9,11-dien-13-one
• IUPAC传统名: (-)-securinine

产品登记号

• MDL号: MFCD00078775
• CAS号: 5610-40-2

产品性质

• Empirical Formula (Hill Notation): C13H15NO2
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 比旋光度: [α]/D -980 to -1015 ( C=1, MeOH)
• 溶解度: DMSO: ≥25 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• RTECS编号: VS4115000
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

详细说明 (简体中文)

Biochem/physiol Actions
Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.