Safinamide mesylate salt

• 产品号: SML0025
• CAS号: 202825-46-5
• 分子式: C18H23FN2O5S
• 分子量: 398.4490232
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Safinamide mesylate salt
• IUPAC标准名: (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide; methanesulfonic acid
• IUPAC传统名: methanesulfonic acid; safinamide
• 别名: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

产品登记号

• CAS号: 202825-46-5
• MDL号: MFCD15145475

产品性质

• Empirical Formula (Hill Notation): C17H19FN2O2 · xCH4O3S
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 比旋光度: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• 溶解度: H2O: ≥15 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

详细说明 (简体中文)

Biochem/physiol Actions
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.