Ac-PGP trifluoroacetate salt hydrate

• 产品号: A2112
• CAS号: 292171-04-1(freebase)
• 分子式: C16H24F3N3O8
• 分子量: 443.3722696
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Ac-PGP trifluoroacetate salt hydrate
• IUPAC标准名: (2S)-1-(2-{[(2S)-1-acetylpyrrolidin-2-yl]formamido}acetyl)pyrrolidine-2-carboxylic acid trifluoroacetic acid hydrate
• IUPAC传统名: (2S)-1-(2-{[(2S)-1-acetylpyrrolidin-2-yl]formamido}acetyl)pyrrolidine-2-carboxylic acid trifluoroacetic acid hydrate
• 别名: Acetyl Pro-Gly-Pro; Acetyl-proline-glycine-proline; 1-Acetyl-L-prolylglycyl-L-proline; N-α-PGP; acPGP

产品登记号

• CAS号: 292171-04-1(freebase)
• MDL号: MFCD20134196

产品性质

• Empirical Formula (Hill Notation): C14H21N3O5 · xC2HF3O2 · yH2O
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 外观: white to tan powder
• 溶解度: deionized water: ≥2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase-8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.

详细说明 (简体中文)

Biochem/physiol Actions
N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase-8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.