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MCOPPB trihydrochloride hydrate

产品号 PZ0159 公司名称 Sigma Aldrich
CAS号 1028969-49-4(freebase) 公司网站 http://www.sigmaaldrich.com
分子式 C26H45Cl3N4O 电 话 1-800-521-8956
分子量 536.0207 传 真
纯 度 >98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 155023

产品价格信息

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产品别名

标题
MCOPPB trihydrochloride hydrate
IUPAC标准名
1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-(piperidin-3-yl)-1H-1,3-benzodiazole hydrate trihydrochloride
IUPAC传统名
1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-(piperidin-3-yl)-1,3-benzodiazole hydrate trihydrochloride
别名
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate

产品登记号

CAS号 1028969-49-4(freebase)

产品性质

Empirical Formula (Hill Notation) C26H40N4 · 3 HCl · xH2O
纯度 >98% (HPLC)
外观 white to tan powder
溶解度 H2O: ≥13 mg/mL
MSDS下载 下载链接
保存温度 room temp
德国WGK号 3

产品详细信息

详细说明 (English)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
详细说明 (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

参考文献