FR-171113

• 产品号: SML0028
• CAS号: 173904-50-2
• 分子式: C19H11Cl3N2O4S
• 分子量: 469.72564
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: FR-171113
• IUPAC标准名: methyl 2-[3-(4-chlorophenyl)-2-(2,4-dichlorobenzamido)-4-oxo-1,3-thiazolidin-5-ylidene]acetate
• IUPAC传统名: methyl 2-[3-(4-chlorophenyl)-2-(2,4-dichlorobenzamido)-4-oxo-1,3-thiazolidin-5-ylidene]acetate
• 别名: FR-171113; 2-[3-(4-chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid, methyl ester

产品登记号

• CAS号: 173904-50-2

产品性质

• Empirical Formula (Hill Notation): C19H11Cl3N2O4S
• 纯度: ≥98% (HPLC)
• 外观: powder
• 溶解度: DMSO: ≥5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H410
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P501
• 危险公开号: 50/53
• 安全公开号: 60-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.

详细说明 (简体中文)

Biochem/physiol Actions
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.