SL327

• 产品号: S4069
• CAS号: 305350-87-2
• 分子式: C16H12F3N3S
• 分子量: 335.3467896
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: SL327
• IUPAC标准名: 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
• IUPAC传统名: 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
• 别名: α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile

产品登记号

• CAS号: 305350-87-2
• MDL号: MFCD06411432

产品性质

• Empirical Formula (Hill Notation): C16H12F3N3S
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 熔点: 127-128.2 °C
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存条件: desiccated
• 保存条件: protect from light
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

详细说明 (简体中文)

Biochem/physiol Actions
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.