KB-R7943

• 产品号: K4144
• CAS号: 182004-64-4(freebase)
• 分子式: C17H21N3O6S2
• 分子量: 427.49514
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: KB-R7943
• IUPAC标准名: [(2-{4-[(4-nitrophenyl)methoxy]phenyl}ethyl)sulfanyl]methanimidamide; methanesulfonic acid
• IUPAC传统名: (2-{4-[(4-nitrophenyl)methoxy]phenyl}ethyl)sulfanylmethanimidamide; methanesulfonic acid
• 别名: 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1); Carbamimidothioic acid

产品登记号

• MDL号: MFCD00952138
• CAS号: 182004-64-4(freebase)

产品性质

• Empirical Formula (Hill Notation): C16H17N3O3S·CH3SO3H
• 纯度: ≥98% (HPLC)
• 外观: off-white to tan powder
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H400
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273
• 危险公开号: 50
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane.

详细说明 (简体中文)

Biochem/physiol Actions
KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane.