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(2S,3S)-Hydroxybupropion hydrochloride_分子结构_CAS_106083-71-0)
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(2S,3S)-Hydroxybupropion hydrochloride

产品号 H3167 公司名称 Sigma Aldrich
CAS号 106083-71-0 公司网站 http://www.sigmaaldrich.com
分子式 C13H19Cl2NO2 电 话 1-800-521-8956
分子量 292.20146 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 154967

产品价格信息

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产品别名

标题
(2S,3S)-Hydroxybupropion hydrochloride
IUPAC标准名
(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol hydrochloride
IUPAC传统名
radafaxine hydrochloride
别名
GW 353162
(2S,3S)-Hydroxybupropion hydrochloride
(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride
(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride
Radafaxine hydrochloride
SS-hydroxybupropion hydrochloride

产品登记号

MDL号 MFCD10565921
CAS号 106083-71-0

产品性质

Empirical Formula (Hill Notation) C13H18ClNO2 · HCl
纯度 ≥98% (HPLC)
外观 white to tan powder
溶解度 DMSO: ≥12 mg/mL
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H319
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
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GHS警示性声明 P305 + P351 + P338
危险公开号 36
安全公开号 26
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
(2S,3S)-hydroxybupropion is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. (2S,3S)-hydroxybupropion is a major metabolite of bupropion. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice.
详细说明 (简体中文)
Biochem/physiol Actions
(2S,3S)-hydroxybupropion is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. (2S,3S)-hydroxybupropion is a major metabolite of bupropion. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice.

参考文献