RS-127445 hydrochloride

• 产品号: R2533
• CAS号: 199864-86-3
• 分子式: C17H17ClFN3
• 分子量: 317.7883832
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: RS-127445 hydrochloride
• IUPAC标准名: 4-(4-fluoronaphthalen-1-yl)-6-(propan-2-yl)pyrimidin-2-amine hydrochloride
• IUPAC传统名: 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine hydrochloride
• 别名: 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride

产品登记号

• MDL号: MFCD11112196
• CAS号: 199864-86-3

产品性质

• Empirical Formula (Hill Notation): C17H16FN3 · HCl
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H315-H319-H335
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P261-P301 + P310-P305 + P351 + P338
• 危险公开号: 25-36
• 安全公开号: 26-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

详细说明 (简体中文)

Biochem/physiol Actions
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.