NKH 477

• 产品号: N3290
• 分子式: C27H44ClNO8
• 分子量: 546.09316
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: NKH 477
• IUPAC标准名: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-6-yl 3-(dimethylamino)propanoate hydrochloride
• IUPAC传统名: colforsin hydrochloride
• 别名: Colforsin dapropate hydrochloride; N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride

产品登记号

• MDL号: MFCD00236421

产品性质

• Empirical Formula (Hill Notation): C27H43NO8·HCl
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: H2O: ≥25 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P264-P301 + P310
• 危险公开号: 28
• RTECS编号: AY5992600
• 安全公开号: 28-36/37-45
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).

详细说明 (English)

Biochem/physiol Actions
NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).