Necrostatin-7

• 产品号: N3040
• CAS号: 351062-08-3
• 分子式: C16H10FN5OS2
• 分子量: 371.4119032
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Necrostatin-7
• IUPAC标准名: 5-{[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
• IUPAC传统名: 5-{[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
• 别名: Nec-7; 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone

产品登记号

• CAS号: 351062-08-3
• MDL号: MFCD02334728

产品性质

• Empirical Formula (Hill Notation): C16H10FN5OS2
• 纯度: ≥98% (HPLC)
• 外观: yellow to tan powder
• 溶解度: DMSO: >10 mg/mL (with warming)
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.

详细说明 (English)

Biochem/physiol Actions
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.