VU0357121

• 产品号: SML0019
• CAS号: 433967-28-3
• 分子式: C17H17F2NO2
• 分子量: 305.3191864
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: VU0357121
• IUPAC标准名: 4-butoxy-N-(2,4-difluorophenyl)benzamide
• IUPAC传统名: 4-butoxy-N-(2,4-difluorophenyl)benzamide
• 别名: VU0357121; 4-Butoxy-N-(2,4-difluorophenyl)-benzamide

产品登记号

• CAS号: 433967-28-3
• MDL号: MFCD03243692

产品性质

• Empirical Formula (Hill Notation): C17H17F2NO2
• 纯度: ≥98% (HPLC)
• 外观: powder
• 溶解度: DMSO: ≥18 mg/mL
• GHS警示词: Warning
• GHS危险声明: H410
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P501
• 危险公开号: 50/53
• 安全公开号: 60-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes.

详细说明 (简体中文)

Biochem/physiol Actions
VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes.