Letrozole

• 产品号: L6545
• CAS号: 112809-51-5
• 分子式: C17H11N5
• 分子量: 285.30274
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Letrozole
• IUPAC标准名: 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]benzonitrile
• IUPAC传统名: letrozole
• 别名: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

产品登记号

• MDL号: MFCD00866241
• CAS号: 112809-51-5

产品性质

• Empirical Formula (Hill Notation): C17H11N5
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >50 mg/mL
• RTECS编号: DI4957000
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

详细说明 (简体中文)

Biochem/physiol Actions
Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.