116-9e

• 产品号: E1036
• CAS号: 831217-43-7
• 分子式: C31H32N2O5
• 分子量: 512.59618
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 116-9e
• IUPAC标准名: 6-{5-[(benzyloxy)carbonyl]-6-methyl-2-oxo-4-(4-phenylphenyl)-1,2,3,4-tetrahydropyrimidin-1-yl}hexanoic acid
• IUPAC传统名: 6-{5-[(benzyloxy)carbonyl]-6-methyl-2-oxo-4-(4-phenylphenyl)-3,4-dihydropyrimidin-1-yl}hexanoic acid
• 别名: 4-[1,1′-Biphenyl]-4-yl-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-1(2H)-pyrimidinehexanoic acid; 116-9e

产品登记号

• MDL号: MFCD18632539
• CAS号: 831217-43-7

产品性质

• Empirical Formula (Hill Notation): C31H32N2O5
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H410
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P301 + P310-P501
• 危险公开号: 25-50/53
• 安全公开号: 45-60-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
116-9e is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co-chaperones binds to Hsp70 through a conserved J-domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70-Hsp40 complex assembly.The same compound by a different name, MAL2-11B, has been found to inhibit the activity of a viral J-domain protein, large tumor antigen (TAg). MAL2-11B inhibited both TAg’s endogenous ATPase activity and the TAg-mediated activation of Hsp70.

详细说明 (English)

Biochem/physiol Actions
116-9e is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co-chaperones binds to Hsp70 through a conserved J-domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70-Hsp40 complex assembly.The same compound by a different name, MAL2-11B, has been found to inhibit the activity of a viral J-domain protein, large tumor antigen (TAg). MAL2-11B inhibited both TAg’s endogenous ATPase activity and the TAg-mediated activation of Hsp70.