AI-1

• 产品号: SML0009
• CAS号: 75483-04-4
• 分子式: C13H12ClNO3
• 分子量: 265.69228
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: AI-1
• IUPAC标准名: ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
• IUPAC传统名: ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
• 别名: Ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate; 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

产品登记号

• MDL号: MFCD00634787
• CAS号: 75483-04-4

产品性质

• Empirical Formula (Hill Notation): C13H12ClNO3
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥15 mg/mL
• GHS警示词: Warning
• GHS危险声明: H317
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P280
• 危险公开号: 43
• 安全公开号: 36/37
• 保存温度: 2-8°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.

详细说明 (简体中文)

Biochem/physiol Actions
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.