Biphenyl-indanone A

• 产品号: B8688
• CAS号: 866823-73-6
• 分子式: C30H30O4
• 分子量: 454.5568
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Biphenyl-indanone A
• IUPAC标准名: 4-(3-{[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl}phenyl)benzoic acid
• IUPAC传统名: biphenylindanone A
• 别名: 3′-[[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl]biphenyl-4-carboxylic acid; Biphenylindanone A; BINA

产品登记号

• MDL号: MFCD19440914
• CAS号: 866823-73-6

产品性质

• Empirical Formula (Hill Notation): C30H30O4
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥18 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Biphenyl-indanone A (BINA) is a potent selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2. In animal studies BINA showed anxiolytic and antipsychotic effects, and blocked the effects produced by the hallucinogenic drug DOB. It decreased cocaine self-administration in rats, with no effect on food self-administration. In recombinant systems, BINA selectively potentiated the response of mGluR2 to glutamate with no effect on the glutamate response of other mGluR receptor subtypes tested.