Lomerizine dihydrochloride

• 产品号: L6295
• CAS号: 101477-54-7
• 分子式: C27H32Cl2F2N2O3
• 分子量: 541.4573864
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Lomerizine dihydrochloride
• IUPAC标准名: 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
• IUPAC传统名: lomerizine dihydrochloride
• 别名: 1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride

产品登记号

• MDL号: MFCD01703867
• CAS号: 101477-54-7

产品性质

• Empirical Formula (Hill Notation): C27H30F2N2O3·2HCl
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥30 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H410
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P501
• 危险公开号: 22-50
• RTECS编号: TK9189000
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.

详细说明 (简体中文)

Biochem/physiol Actions
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.