IU1

• 产品号: I1911
• CAS号: 314245-33-5
• 分子式: C18H21FN2O
• 分子量: 300.3705432
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: IU1
• IUPAC标准名: 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one
• IUPAC传统名: 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-(pyrrolidin-1-yl)ethanone
• 别名: 1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone

产品登记号

• MDL号: MFCD01917473
• CAS号: 314245-33-5

产品性质

• GHS警示词: Danger
• GHS危险声明: H318
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P280-P305 + P351 + P338
• 危险公开号: 41
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 3
• Empirical Formula (Hill Notation): C18H21FN2O
• 纯度: ≥98% (HPLC)
• 外观: off-white to light brown powder
• 溶解度: DMSO: >10 mg/mL

产品详细信息

详细说明 (English)

Biochem/physiol Actions
IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. The proteasome mediates the cellular degradation of oxidized, damaged and misfolded proteins which, if not removed, accumulate and become toxic to cells. Proteins targeted for proteasomal degradation are first ubiquitinated, with longer length ubiquitin chains interacting more strongly with the proteasome. Deubiquitinating enzymes (DUBs) such as USP14 interfere with the degradation process. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.

详细说明 (简体中文)

Biochem/physiol Actions
IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. The proteasome mediates the cellular degradation of oxidized, damaged and misfolded proteins which, if not removed, accumulate and become toxic to cells. Proteins targeted for proteasomal degradation are first ubiquitinated, with longer length ubiquitin chains interacting more strongly with the proteasome. Deubiquitinating enzymes (DUBs) such as USP14 interfere with the degradation process. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.