Bisdemethoxycurcumin

• 产品号: B6938
• 分子式: C19H16O4
• 分子量: 308.32794
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Bisdemethoxycurcumin
• IUPAC标准名: 1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• IUPAC传统名: 1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• 别名: (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

产品登记号

• MDL号: MFCD03419284

产品性质

• Empirical Formula (Hill Notation): C19H16O4
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: ≥20 mg/mL
• 保存温度: 2-8°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.

详细说明 (简体中文)

Biochem/physiol Actions
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.