MDL 72527

• 产品号: M2949
• CAS号: 93565-01-6
• 分子式: C12H22Cl2N2
• 分子量: 265.22248
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: MDL 72527
• IUPAC标准名: (buta-2,3-dien-1-yl)({4-[(buta-2,3-dien-1-yl)amino]butyl})amine dihydrochloride
• IUPAC传统名: buta-2,3-dien-1-yl[4-(buta-2,3-dien-1-ylamino)butyl]amine dihydrochloride
• 别名: N1,N4-Bis(2,3-butadienyl)-1,4-butanediamine hydrochloride; MDL-72527DA; N,N′-Bis(2,3-butadienyl)-1,4-butanediamine dihydrochloride; CPC-200

产品登记号

• MDL号: MFCD13152261
• CAS号: 93565-01-6

产品性质

• Empirical Formula (Hill Notation): C12 H20 N2·2 HCl
• 纯度: ≥98% (HPLC)
• 外观: light yellow to light brown powder
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

详细说明 (简体中文)

Biochem/physiol Actions
MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.