Nebivolol hydrochloride

• 产品号: N1915
• CAS号: 152520-56-4
• 分子式: C22H26ClF2NO4
• 分子量: 441.8959464
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Nebivolol hydrochloride
• IUPAC标准名: (1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino}ethan-1-ol hydrochloride
• IUPAC传统名: l-nebivolol hydrochloride
• 别名: R-65824; rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride; Narbivolol; Nebilet

产品登记号

• CAS号: 152520-56-4

产品性质

• Empirical Formula (Hill Notation): C22H25F2NO4 · HCl
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H410
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-50/53
• 安全公开号: 60-61
• 保存条件: desiccated
• 保存温度: room temp
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).

详细说明 (简体中文)

Biochem/physiol Actions
Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).