RU7

• 产品号: R1408
• CAS号: 355400-87-2
• 分子式: C14H11Br2NO6S
• 分子量: 481.11324
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: RU7
• IUPAC标准名: 2-{5-[(2,3-dibromo-5-ethoxy-4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
• IUPAC传统名: {5-[(2,3-dibromo-5-ethoxy-4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
• 别名: 5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

产品登记号

• CAS号: 355400-87-2

产品性质

• Empirical Formula (Hill Notation): C14H11Br2NO5S2
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: ≥20 mg/mL
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.

详细说明 (简体中文)

Biochem/physiol Actions
RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.