COG 133 trifluoroacetate salt

• 产品号: C8624
• CAS号: 514200-66-9(freebase)
• 分子式: C99H182F3N37O22
• 分子量: 2299.7342896
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: COG 133 trifluoroacetate salt
• IUPAC标准名: trifluoroacetic acid amino (2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-acetamido-4-methylpentanamido]pentanamido]-3-methylbutanamido]pentanamido]-4-methylpentanamido]propanamido]-3-hydroxypropanamido]-3-(1H-imidazol-5-yl)propanamido]-4-methylpentanamido]pentanamido]hexanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-methylpentanamido]-4-methylpentanoate
• IUPAC传统名: trifluoroacetic acid amino (2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-acetamido-4-methylpentanamido]pentanamido]-3-methylbutanamido]pentanamido]-4-methylpentanamido]propanamido]-3-hydroxypropanamido]-3-(3H-imidazol-4-yl)propanamido]-4-methylpentanamido]pentanamido]hexanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-methylpentanamido]-4-methylpentanoate
• 别名: apoE(133-149); Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2; COG133; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide; Ac- LRVRLASHLRKLRKRLL-NH2

产品登记号

• CAS号: 514200-66-9(freebase)
• MDL号: MFCD18432706

产品性质

• Empirical Formula (Hill Notation): C97H181N37O19 · xC2HF3O2
• 纯度: ≥95% (HPLC)
• 外观: white lyophilized
• 溶解度: H2O: >1 mg/mL
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.

详细说明 (简体中文)

Biochem/physiol Actions
COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.