Pristimerin

• 产品号: P0020
• CAS号: 1258-84-0
• 分子式: C30H40O4
• 分子量: 464.6362
• 纯 度: ≥98% (HPLC)
• 保 存: protect from light

产品别名

• 标题: Pristimerin
• IUPAC标准名: methyl (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate
• IUPAC传统名: pristimerin
• 别名: (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26 -trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester

产品登记号

• CAS号: 1258-84-0
• MDL号: MFCD01711331

产品性质

• Empirical Formula (Hill Notation): C30H40O4
• 纯度: ≥98% (HPLC)
• 外观: orange powder
• 溶解度: DMSO: ≥5 mg/mL
• 保存条件: protect from light
• 保存温度: -20°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol (C0869).

详细说明 (简体中文)

Biochem/physiol Actions
More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol (C0869).