PKF118-310

• 产品号: K4394
• CAS号: 84-82-2
• 分子式: C7H7N5O2
• 分子量: 193.16278
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: PKF118-310
• IUPAC标准名: 4,7-dimethyl-4H,6H,7H,8H-pyrimido[4,5-e][1,2,4]triazine-6,8-dione
• IUPAC传统名: 4,7-dimethylpyrimido[4,5-e][1,2,4]triazine-6,8-dione
• 别名: Toxoflavin; 1,6-Dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione; Xanthothricin

产品登记号

• CAS号: 84-82-2

产品性质

• Empirical Formula (Hill Notation): C7H7N5O2
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥15 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P264-P301 + P310
• 危险公开号: 28
• 安全公开号: 45-46
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.

详细说明 (简体中文)

Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.