Dihydroeponemycin

• 产品号: D4321
• CAS号: 126463-64-7
• 分子式: C20H36N2O6
• 分子量: 400.50964
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Dihydroeponemycin
• IUPAC标准名: N-[(1S)-2-hydroxy-1-{[(2S)-1-[(2R)-2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}ethyl]-6-methylheptanamide
• IUPAC传统名: N-[(1S)-2-hydroxy-1-{[(2S)-1-[(2R)-2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}ethyl]-6-methylheptanamide

产品登记号

• MDL号: MFCD17215971
• CAS号: 126463-64-7

产品性质

• Empirical Formula (Hill Notation): C20H36N2O6
• 纯度: ≥98% (HPLC)
• 外观: off-white to light tan powder
• 比旋光度: [α]/D ±35.7°
• 溶解度: DMSO: ≥1 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存温度: 2-8°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.

详细说明 (简体中文)

Biochem/physiol Actions
Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.