Famciclovir

• 产品号: F7932
• CAS号: 104227-87-4
• 分子式: C14H19N5O4
• 分子量: 321.33176
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Famciclovir
• IUPAC标准名: 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
• IUPAC传统名: famciclovir
• 别名: BRL 42810; 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester

产品登记号

• MDL号: MFCD00866964
• CAS号: 104227-87-4

产品性质

• Empirical Formula (Hill Notation): C14H19N5O4
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: ≥10 mg/mL
• RTECS编号: TY3164000
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F7932.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

详细说明 (简体中文)

Biochem/physiol Actions
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F7932.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.