NSC43067

• 产品号: N0915
• CAS号: 26903-26-4
• 分子式: C14H12OS
• 分子量: 228.30948
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: NSC43067
• IUPAC标准名: 1-(5-methylthiophen-2-yl)-3-phenylprop-2-en-1-one
• IUPAC传统名: 1-(5-methylthiophen-2-yl)-3-phenylprop-2-en-1-one
• 别名: NSC 43067; 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone; 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one

产品登记号

• CAS号: 26903-26-4
• MDL号: MFCD00489751

产品性质

• Empirical Formula (Hill Notation): C14H12OS
• 纯度: ≥98% (HPLC)
• 外观: light yellow to light tan powder
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H319-H413
• GHS警示性声明: P305 + P351 + P338
• 保存温度: 2-8°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

详细说明 (简体中文)

Biochem/physiol Actions
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.