Adapalene

• 产品号: A7486
• CAS号: 106685-40-9
• 分子式: C28H28O3
• 分子量: 412.52012
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Adapalene
• IUPAC标准名: 6-{4-methoxy-3-[(3R,5S,7s)-adamantan-1-yl]phenyl}naphthalene-2-carboxylic acid
• IUPAC传统名: adapaleno [inn-spanish]
• 别名: 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid; Differin; CD-271; 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

产品登记号

• MDL号: MFCD03106112
• CAS号: 106685-40-9

产品性质

• Empirical Formula (Hill Notation): C28H28O3
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >10 mg/mL
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: nwg

产品详细信息

详细说明 (简体中文)

Application
Adapalene, a retinoic acid analogue, is a RARβ and RARγ agonist. Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene gel is an efficacious treatment for acne vulgaris.
Biochem/physiol Actions
Retinoic acid analogue that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Displays comedolytic activity. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.

详细说明 (English)

Application
Adapalene, a retinoic acid analogue, is a RARβ and RARγ agonist. Adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene gel is an efficacious treatment for acne vulgaris.
Biochem/physiol Actions
Retinoic acid analogue that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Displays comedolytic activity. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.