NS5806

• 产品号: N2540
• CAS号: 426834-69-7
• 分子式: C16H8Br2F6N6O
• 分子量: 574.0727392
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: NS5806
• IUPAC标准名: 3-[3,5-bis(trifluoromethyl)phenyl]-1-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea
• IUPAC传统名: 3-[3,5-bis(trifluoromethyl)phenyl]-1-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea
• 别名: N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea

产品登记号

• MDL号: MFCD18432708
• CAS号: 426834-69-7

产品性质

• Empirical Formula (Hill Notation): C16H8Br2F6N6O
• 纯度: ≥98% (HPLC)
• 外观: white to faint yellow powder
• 溶解度: DMSO: >30 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H413
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P301 + P310
• 危险公开号: 25
• 安全公开号: 45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.

详细说明 (简体中文)

Biochem/physiol Actions
NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.