VU0238429

• 产品号: V4515
• CAS号: 1160247-92-6
• 分子式: C17H12F3NO4
• 分子量: 351.2766896
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: VU0238429
• IUPAC标准名: 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione
• IUPAC传统名: 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione
• 别名: 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

产品登记号

• MDL号: MFCD16618396
• CAS号: 1160247-92-6

产品性质

• Empirical Formula (Hill Notation): C17H12F3NO4
• 纯度: ≥98% (HPLC)
• 外观: orange powder
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H319-H400
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P305 + P351 + P338
• 危险公开号: 36-50/53
• 安全公开号: 26-60-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

详细说明 (简体中文)

Biochem/physiol Actions
VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.