Hypothemycin

• 产品号: H1667
• CAS号: 76958-67-3
• 分子式: C19H22O8
• 分子量: 378.37318
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Hypothemycin
• IUPAC标准名: (2R,4R,6S,7S,12S)-6,7,16-trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.0^2,^4]nonadeca-1(19),9,15,17-tetraene-8,14-dione
• IUPAC传统名: (2R,4R,6S,7S,12S)-6,7,16-trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.0^2,^4]nonadeca-1(19),9,15,17-tetraene-8,14-dione
• 别名: NSC354462; 3H-Oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione,1a,8,9,15b-tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-,(1aR,3S,4S,6Z,9S,15bR)-

产品登记号

• CAS号: 76958-67-3
• MDL号: MFCD08457932

产品性质

• 生物来源: from Hypomyces trichothecoides
• Empirical Formula (Hill Notation): C19H22O8
• 纯度: ≥98% (HPLC)
• 溶解度: DMSO: soluble
• 溶解度: acetone: soluble
• 溶解度: deionized water: insoluble
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Hypothemycin, one of the highly oxygenated analogues in the group of 14-membered resorcylic acid lactones (RAL),1,2,3 has minor antifungal and cytotoxic activity and exhibits an in vitro anti-malarial activity with an IC50 of 2.2 μg/mL.4 Hypothemycin is also reported to selectively and irreversibly inhibit protein kinases that contain a conserved cysteine residue (Cys166) that is located within the ATP-binding domain.1,2,3,5 Though this group accounts for less then 10% of all identified kinases, there are several targets implicated in aberrant cellular proliferation such as ERKs, MEK, FMS-like tyrosine kinase protein (FLT), and platelet-derived growth factor receptors (PDGFR).1 In cell culture, hypothemycin displays potent cytotoxicity against cancer cell lines that are dependent on certain activating kinase mutations. Additionally, hypothemycin demonstrates significant tumor growth inhibition in at least three separate murine xenograft models.1,5 Hypothemycin also inhibits the production of several cytokines such as IL2, IL6, IFNγ, and TNFα.5

详细说明 (简体中文)

Biochem/physiol Actions
Hypothemycin, one of the highly oxygenated analogues in the group of 14-membered resorcylic acid lactones (RAL),1,2,3 has minor antifungal and cytotoxic activity and exhibits an in vitro anti-malarial activity with an IC50 of 2.2 μg/mL.4 Hypothemycin is also reported to selectively and irreversibly inhibit protein kinases that contain a conserved cysteine residue (Cys166) that is located within the ATP-binding domain.1,2,3,5 Though this group accounts for less then 10% of all identified kinases, there are several targets implicated in aberrant cellular proliferation such as ERKs, MEK, FMS-like tyrosine kinase protein (FLT), and platelet-derived growth factor receptors (PDGFR).1 In cell culture, hypothemycin displays potent cytotoxicity against cancer cell lines that are dependent on certain activating kinase mutations. Additionally, hypothemycin demonstrates significant tumor growth inhibition in at least three separate murine xenograft models.1,5 Hypothemycin also inhibits the production of several cytokines such as IL2, IL6, IFNγ, and TNFα.5