Cucurbitacin B hydrate_分子结构_CAS_6199-67-3(anhydrous))

2D 3D 下载放大

Cucurbitacin B hydrate
产品号	C8499	公司名称	Sigma Aldrich
CAS号	6199-67-3(anhydrous)	公司网站	http://www.sigmaaldrich.com
分子式	C32H48O9	电话	1-800-521-8956
分子量	576.71812	传真
纯度	≥98% (HPLC)	电子邮件
保存		Chembase数据库ID: 154800

产品价格信息

请登录

产品别名

标题

Cucurbitacin B hydrate

IUPAC标准名

(6R)-6-[(1R,2R,4S,10S,11S,13R,14R,15R)-4,13-dihydroxy-1,6,6,11,15-pentamethyl-5,17-dioxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate hydrate

IUPAC传统名

(6R)-6-[(1R,2R,4S,10S,11S,13R,14R,15R)-4,13-dihydroxy-1,6,6,11,15-pentamethyl-5,17-dioxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate hydrate

别名

(2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione

产品登记号

MDL号	MFCD18432707
CAS号	6199-67-3(anhydrous)

产品性质

Empirical Formula (Hill Notation)	C32H46O8 · xH2O
纯度	≥98% (HPLC)
外观	off-white to light brown powder
溶解度	DMSO: ≥20 mg/mL
GHS危险品标识
GHS警示词	Danger
GHS危险声明	H300
欧盟危险性物质标志	有毒(Toxic) (T)
MSDS下载	下载链接
GHS警示性声明	P264-P301 + P310
危险公开号	25
安全公开号	45
保存温度	2-8°C
德国WGK号	3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.

详细说明 (简体中文)

Biochem/physiol Actions
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.