DMH4

• 产品号: D8696
• CAS号: 515880-75-8
• 分子式: C24H24N4O2
• 分子量: 400.47296
• 纯 度: >99.0% (HPLC)
• 保 存: desiccated

产品别名

• 标题: DMH4
• IUPAC标准名: 4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phenoxy)ethyl]morpholine
• IUPAC传统名: 4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phenoxy)ethyl]morpholine

产品登记号

• CAS号: 515880-75-8
• MDL号: MFCD18452839

产品性质

• Empirical Formula (Hill Notation): C24H24 N4O2
• 纯度: >99.0% (HPLC)
• 外观: off-white to brown powder
• 溶解度: DMSO: soluble20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.

详细说明 (简体中文)

Biochem/physiol Actions
DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.