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Levosimendan

产品号 L5545 公司名称 Sigma Aldrich
CAS号 141505-33-1 公司网站 http://www.sigmaaldrich.com
分子式 C14H12N6O 电 话 1-800-521-8956
分子量 280.28468 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 798

产品价格信息

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产品别名

标题
Levosimendan
IUPAC标准名
1-cyano-N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}methanecarbohydrazonoyl cyanide
IUPAC传统名
levosimendan
别名
(R)-Simendan
R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono) propanedintrile
OR 1259
2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile
(-)-OR-1259

产品登记号

MDL号 MFCD00867135
CAS号 141505-33-1

产品性质

Empirical Formula (Hill Notation) C14H12N6O
纯度 ≥98% (HPLC)
外观 yellow powder
比旋光度 [α]/D -500 to -650°, c = 0.5 in THF
溶解度 DMSO: ≥20 mg/mL
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H302-H312-H332
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
GHS警示性声明 P280
危险公开号 20/21/22
RTECS编号 TY1570210
安全公开号 36/37
保存温度 room temp
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Levosimendan is a calcium sensitiser. The compound increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan binds to cardiac troponin C in a calcium-dependent manner and stabilizes troponin C. This is followed by actin-myosin cross-bridges, without increasing myocardial consumption of ATP. Additionally the compound acts as vasodilator by opening an ATP-sensitive potassium channels. Levosimendan is a drug used for treatment of congestive heart failure. Also it can be used to treat calcium channel blocker overdose.
详细说明 (简体中文)
Biochem/physiol Actions
Levosimendan is a calcium sensitiser. The compound increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan binds to cardiac troponin C in a calcium-dependent manner and stabilizes troponin C. This is followed by actin-myosin cross-bridges, without increasing myocardial consumption of ATP. Additionally the compound acts as vasodilator by opening an ATP-sensitive potassium channels. Levosimendan is a drug used for treatment of congestive heart failure. Also it can be used to treat calcium channel blocker overdose.

参考文献